This book explores the evolving frontiers of periodontology, integrating cutting-edge insights into the periodontal microbiome, systemic health interactions, regenerative therapies, and precision diagnostics. It bridges clinical dentistry with biomedical innovation, highlighting the role of periodontitis in systemic disease and advancing interdisciplinary strategies for prevention and care. Emphasizing the integration of artificial intelligence, host modulation, and molecular diagnostics, the book presents a forward-looking view of personalized periodontics. Contributions from a diverse team of researchers and clinicians provide a comprehensive resource for understanding how innovations in microbiology, immunology, and bioactive therapies are transforming periodontal practice and research. A must-read for clinicians, researchers, and students seeking to stay ahead in evidence-based, personalized care.