The De Gruyter Handbook of Digital Health and Society explores how digitalization is reconfiguring practices of health and medicine. Digitalisation requires health and medical practices to address and utilise the interrelated challenges posed by increased quantification (e.g., data-intensive medicine), ubiquitous connectivity (e.g., remote access to care providers), and the unprecedented power of algorithms (e.g., communicative AI). Developing important social scientific analyses of the contemporary sociotechnical configuration of health knowledge, therapeutic relationships and medical decision-making, the handbook puts forward theories and methods to inform the development, implementation and governance of Digital Health. It will therefore be an invaluable resource for shaping desirable futures in health and care.