This book constitutes selected papers presented at the the 4th International Conference on Science, Engineering Management and Information Technology, SEMIT 2024, held in Ankara, Turkey, during September 12–13, 2024. The 27 full papers included in this book were carefully reviewed and selected from 123 submissions. These papers were organized in the following topical sections: Advances of AI/ML and Optimization in IT and Engineering; Novel AI Techniques in Healthcare and Medicine; Digital Technologies for Customer Service Orientation and Social Sustainability; Applications of AI/ML/DL in Traffic and Transportation Engineering.