This book constitutes the refereed proceedings of the 1st International Conference on Advances in Smart Computing and Applications, ICASCA 2025, held in Ahmedabad, India, during February 15–16, 2025. The 25 full papers were presented in this volume were carefully reviewed and selected from 112 submissions. They focus on Machine Learning, Deep Learning, Transfer Learning, Neural Computing, Artificial Intelligence, Reinforcement Learning, Recommendation systems, Soft computing, Intelligent Systems, Pattern Recognition, Natural Language Processing, Big Data Analytics, Networks, Text Mining, Web Mining, Data Streams, Image Processing, Distributed Databases, Block Chain.