Comprehensive coverage of sustainable multicomponent reactions across multiple disciplines Multicomponent reactions enable the combination of three or more starting materials in a single vessel to afford diverse and complex products while aligning with green chemistry principles. This two-volume work summarizes the most recent MCR applications and emerging trends, providing expert knowledge on current advancements across organic chemistry, medicinal chemistry, polymer and analytical chemistry. The book explores sustainable chemical approaches, such as electrochemistry, photochemistry, mechanochemistry, and flow chemistry. It also covers biocatalytic MCRs, reactions in non-conventional solvents, isotope labeling, and late-stage functionalization. Additional topics include:* Artificial intelligence and automated synthesis (HTS) enhancing MCRs workflows in research laboratories* Drug discovery applications demonstrating how MCRs rapidly generate diverse chemical libraries of heterocycles and bioactive compounds, including protein degraders* Reactive intermediates and reaction mechanisms in multicomponent processes * Innovative approaches for designing advanced materials with specific functional properties * MCRs in chemical education This comprehensive book will benefit organic chemists, medicinal chemists, materials scientists, and chemical engineers, providing them with practical knowledge of sustainable synthetic methods from expert contributors across various research fields.