This book constitutes the refereed proceedings of the 16th International Symposium on Computer Music Multidisciplinary Research, CMMR 2023, held in Tokyo, Japan, during November 13–17, 2023. The 37 full papers included in this book were carefully reviewed and selected from 120 submissions. They were organized in topical sections as follows: Artificial intelligence, cognitive science and skillscience for sound and music; music and sound generation: Emerging approaches and diverse applications; computational research on music evolution; computational musicology; music recognition and creation tools; music information retrieval; and audio signal processing and HCI in music.